| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e81dcc6a2a3760d1fcbdb615804dac36 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-21004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-70 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-21004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22 |
| filingDate |
2021-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfffcfd5f6db2df2af87466345809107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6b4fecf4ea20b02e415057a9b7098f0 |
| publicationDate |
2021-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2021146622-A1 |
| titleOfInvention |
Induction of dna strand breaks at chromatin targets |
| abstract |
One aspect of this disclosure relates to a composition of matter. The composition of matter comprises a nucleotide construct encoding a peptide. The peptide includes at least a targeting domain configured to bind to chromatin having a pattern of reduced epigenetic repression, and a DNA strand break inducing domain. When accumulated through binding at chromatin sites, the strand break inducing domain may cause specific, double-strand breaks to the DNA, inducing cell death in cells exhibiting the pattern of reduced epigenetic repression. |
| priorityDate |
2020-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |