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filingDate 2021-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16634000c08932339bb9a701e6aecc48
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publicationDate 2021-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2021143959-A1
titleOfInvention Method for separation of sperm with undamaged intact heads from sperm with damaged heads and somatic cells
abstract The present invention provides a method of separation of sperm cells with undamaged intact heads from sperm cells with damaged heads and/or somatic cells and/or cell debris in a sperm sample obtained from a human, comprising the steps of: - providing an anti-CD46 antibody or CD46-binding ligand bound to a carrier and/or to a tag; - contacting the sperm sample with the anti-CD46 antibody or CD46-binding ligand bound to the carrier and/or to the tag in order to bind CD46 presenting cells and/or cell debris from the sperm sample to the anti-CD46 antibody or CD46-binding ligand; - removing the CD46 presenting cells bound via the anti-CD46 antibody or CD46-binding ligand to the carrier and/or to the tag to obtain a sperm sample free of CD46 presenting cells, wherein CD46 presenting cells include sperm cells with damaged heads, somatic cells and cell debris. The technology of the invention is in particular designed to separate sperm with undamaged intact heads to be further used in assisted reproduction, human medicine and/or research.
priorityDate 2020-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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