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filingDate 2021-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_492b2842a689a681e20f41ea96f002f4
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publicationDate 2021-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2021141852-A1
titleOfInvention Method for performing multiple analyses on same nucleic acid sample
abstract Provided herein is a method for sample analysis. In some embodiments, the method may involve: (a) incubating a nucleic acid sample with a terminal transferase and a cyclooctene-functionalized nucleotide to produced cyclooctene-functionalized nucleic acid molecules; (b) tethering the cyclooctene-functionalized nucleic acid molecules to a tetrazine-functionalized support via an Alder cycloaddition reaction; (c) performing at least two separate primer extension reactions using the tethered nucleic acid molecules as a template to produce multiple distinct sets of primer extension products; (d) separately analyzing the sets of primer extension products using different methods to produce multiple data sets; and (e) integrating the data sets.
priorityDate 2020-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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