http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021140471-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_957bcaa32ded75fe81588cf81da08ddb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-167 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-167 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2021-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19e44be65d48be5f4ad31b6455acf5d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a444248c70f9f23adf9a3d6331bc079 |
| publicationDate | 2021-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2021140471-A1 |
| titleOfInvention | Method for synthesis of 2'-alkyl- or 2'-alkenyl- or 2'-alkynyl-4'-fluoro-adenosine derivatives and intermediates thereof |
| abstract | A method of making nucleoside 1, which has a 3-hydrocarbyl-5-fluoro-5-(hydroxy-methyl)tetrahydrofuran-3,4-diol ring system, where hydrocarbyl group R1 is lower alkyl, lower alkenyl, or lower alkynyl and R2 may be an adenine moiety having an exocyclic amino group protected as an imidodicarbonate or as a carbamate. Nucleoside 1 is prepared from an intermediate 4 by adding iodine fluoride across the exocyclic double bond to produce a 5-fluoro-5-iodomethyl derivative 5. The iodine atom is displaced with a carboxylic acid nucleophile in the presence of an oxidizing agent to produce a 5-fluoro-5-(acyloxy)methyl ester derivative 7, where R3 is an acyl group. Ester 7 may be converted into compound 1 by cleavage of the ester. |
| priorityDate | 2020-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 265.