| abstract |
The present invention relates to a method for preparing a coumarin compound, the 3 position of which is substituted with an amidoalkyl, and related intermediates thereof. The method includes: step (A): reacting a compound of formula (VI) with a compound of formula (V) to prepare a compound of formula (VII). In the formulae, R1 and R2 are each independently selected from hydrogen, halogen and -O(C1-8 alkyl), wherein the alkyl is optionally substituted with 1 or 2 groups selected from the following: halogen, C1-8 alkyl substituted with 1-2 hydroxyls, and -O(C1-8 alkyl); R3 is -L-C(O)NR5R6, and L is C1-3 alkylene. |