| abstract |
Disclosed are an insulin derivative, a pharmaceutical preparation thereof, a pharmaceutical composition thereof combined with a long-acting GLP-1 compound, and the medical use of the insulin derivative, pharmaceutical preparation and pharmaceutical composition. Compared with insulin degludec or other insulin derivatives, the insulin derivative has an unexpected significant increase in efficacy, a longer duration of action, a longer in vivo half-life, a good bioavailability, and a better physical and chemical stability. |