| abstract |
Provided is an IL-36R signal-specific inhibitory antibody that is an IL-36R neutralizing antibody specifically binding to human IL-36R and inhibiting the signals of IL-36R agonists and that shows little or no inhibition of the signal of IL-36β from among IL-36α, IL-36β and IL-36γ. This antibody shows a 10 times or higher half maximal inhibitory concentration (IC 50 ) for the signal of at least one ligand from among three human IL-36R agonist ligands IL-36α, IL-36β and IL-36γ than the half maximal inhibitory concentration for the signal of at least one of the other ligands. |