| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ea17ba87480b776cce77451f86b25bb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-48 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-50 |
| filingDate |
2020-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1030e47be99f94e4348e630cc0c0b64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f151f7dc65ba85a4c40eeaa806a0d4b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b617a29f87b0fdfc12a5d7f3f8493f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_287f03f70e1b728ae8b0afa5c0e18502 |
| publicationDate |
2021-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2021130163-A1 |
| titleOfInvention |
A process for the synthesis of melphalan |
| abstract |
The invention relates to a process for the preparation of Melphalan (4-[bis(2-5 chloroethyl)amino]-L-phenylalanine of formula (I) said process comprising the reaction of a 4-amino-L-phenylalanine protected at the carboxy and amino aminoacidic groups with an agent able to convert the aromatic amino group into a group of formula: -N(CH 2 CH 2 OS(O) n O-) 2 , wherein n is 1 or 2 followed by conversion of the –-N(CH 2 CH 2 OS(O) n O-) 2 group into a -N(CH 2 CH 2 Cl) 2 group. The invention also provides novel intermediates useful for the preparation of Melphalan. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114315618-A |
| priorityDate |
2019-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |