http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021128232-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4a0e7f72522372164da08c67ed841c13 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-39 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-8968 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-8968 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 |
| filingDate | 2019-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58320c7cedc6c9bd5f3ccc6768802a26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ee25f77159d3e48ab7318e102f672d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_959ac253f7de497c7bc39a1991a7cc41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3110b4933b0791b18147cf40ec3005b |
| publicationDate | 2021-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2021128232-A1 |
| titleOfInvention | Ophiopogonis radix degradation extract and use thereof in preparation of hypoglycemic drugs |
| abstract | Provided is an Ophiopogonis radix degradation extract with higher hypoglycemic activity. The preparation method comprises: extracting medicinal materials with water 1 to 3 times, for 0.5 to 2 hours each time and according to a liquid-to-solid ratio of 5 to 20, filtering the medicinal materials, concentrating the filtrate to obtain an extract with a raw material content of 0.5 to 2 g/ml, adding ethanol to enable the alcohol content to reach 75％ to 90％, precipitating the extract and evaporating to dryness to obtain crude Ophiopogonis radix polysaccharide; carrying out deproteinization and purification by using a Sevage method; and after purification, adding water for full dissolution to a transparent state, adding 2 mol/L of an acid according to a solid-to-liquid ratio of 10: 1, carrying out degradation for 4-6 hours, adding an alkaline solution until same is neutral, carrying out ultrafiltration interception to obtain a degradation product with a molecular weight range of 500-2500, concentrating the degradation product, and carrying out freeze drying to obtain the product. Compared with the prior art, the above-mentioned extract has higher activity with regard to reducing blood sugar, and is obviously superior to crude Ophiopogonis polysaccharide radix and other Ophiopogonis radix small-molecule polysaccharides obtained by means of the existing methods. The yield can reach at least 95％, the method is simple and easy to implement, and large-scale production can be achieved. |
| priorityDate | 2019-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 120.