| abstract |
The present invention relates to a substituted alkynyl heterocyclic compound shown in formula I. The present invention relates to the substituted alkynyl heterocyclic compound having SHP2 inhibitory activity, a preparation method therefor, and a pharmaceutical composition thereof, and also relates to uses of the compound and the pharmaceutical composition thereof in treatment of diseases that benefit from SHP2 enzyme inhibition, such as treatment of cancers. In the preparation process, the compound of formula I is obtained by reactions such as iodination, amination, protection, coupling, deprotection, and a ring-closing reaction. |