http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021119395-A1

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filingDate 2020-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0e8b6481b4c590207ae1990e880f364
publicationDate 2021-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2021119395-A1
titleOfInvention Systems and methods for detecting infections
abstract Provided herein are systems and methods configured for the collection of breath samples to allow for the detection of respiratory and systemic infections in a subject (e.g., a human patient) in conjunction with delivery of a drug to the subject. The drug may be configured t be metabolized by putative urease pathogens colonizing and/or infecting the subject. The metabolism of the drug by the putative urease pathogens produces elevations in the abundance of 13C02 in the patient's breath samples. Further, the described systems and methods involve collection of one or more baseline breath sample before introduction of the drug into the subject's respiratory airway, as well as one or more breath samples collected a selected period or periods after the completion of the drug delivery. Comparing the abundance o 13C02 in the post-administration sample(s) to the abundance of 13C02 in the baseline sample(s) allows for the detection of urea metabolizing infections of interest.
priorityDate 2019-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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