| abstract |
The present invention provides a cosmetic composition for suppression or alleviation of seborrhea and a pharmaceutical composition for prevention, alleviation, and treatment of seborrhea, each composition comprising a specific peptide as an active ingredient. The peptide remarkably decreases the interaction between p53 and MDM2, with the consequent remarkable increase of the interaction between p53 and RNA Polymerase II (POLII), whereby the peptide can induce the expression of a cytokine that induces the apoptosis of sebocytes. |