| abstract |
The present invention provides a deuterated N,N-dimethyltryptamine compound or a plurality of deuterated N,N-dimethyltryptamine compounds for use in therapy, selected from N,N-dimethyltryptamine compounds, α-protio, α-deutero-N,N- dimethyltryptamine compounds, α,α-dideutero-N,N-dimethyltryptamine compounds, and pharmaceutically acceptable salts of these compounds, preferably wherein the deuterated N,N-dimethyltryptamine compound has an increased half-life when compared with the half-life of undeuterated N,N-dimethyltryptamine. In particular the invention provides a compound of Formula I, or a pharmaceutically acceptable salt thereof; (I) wherein the ratio of deuterium:protium in the compound is greater than that found naturally in hydrogen; each R1 is independently selected from H and D; R2 is selected from CH3 and CD3; R3 is selected from CH3 and CD3; and each yH is independently selected from H and D. Methods of synthesising compounds of the present invention, and methods of use of such compositions in treating psychiatric or neurological disorders, such as major depressive disorder, are also provided. |