| titleOfInvention |
Method for maturing cardiomyocyte, method for evaluating maturation degree of cardiomyocyte, method for purifying mature cardiomyocyte, method for assisting drug development, method for treating heart disease, mature cardiomyocyte marker, reporter cell, mature cardiomyocyte, device for evaluating maturation degree of cardiomyocyte, program for evaluating maturation degree of cardiomyocyte, kit for maturing cardiomyocyte, and kit for purifying cardiomyocyte |
| abstract |
Provided is a method for maturing a cardiomyocyte, whereby it becomes possible to obtain a maturated mature cardiomyocyte. One component selected from the group consisting of a specific nuclear receptor agonist, a maturation-promoting compound and a transcriptional factor capable of promoting the maturation of a cardiomyocyte or an arbitrary combination of these components is added to an immature cardiomyocyte. As a result, the immature cardiomyocyte can be matured to give a mature cardiomyocyte. Among the above-mentioned components, a nuclear receptor agonist is one component selected from the group consisting of a hormone, an RXR agonist, a PPAR agonist and an ROR agonist or an arbitrary combination of these components, and the maturation-promoting compound is an HIF1a inhibitor. |