| abstract |
The invention describes a non-naturally occurring bacteria modified genetically to produce tryptophan derived compounds including N,N-Dimethyltryptamine. The modified bacteria is preferably Escherichia coli or Zymomonas mobilis and it is modified to express the one or more Tryptophan Decarboxylase (Aromatic Amino acid Decarboxylase, AADC) enzyme, Indolethylamine N-methyltransferase (INMT) enzyme, N-methyltransferase (INMT) enzyme, Tryptophan hydroxylyase, Tryptamine-5-hydroxylyase enzyme, and Hydroxyindole-O-Methyltransferase enzyme. |