http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021110918-A1

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filingDate 2020-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ab58317c699d27dff2340e48b45d65d
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publicationDate 2021-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2021110918-A1
titleOfInvention Method for analyzing the metabolic content of a biological sample
abstract The invention relates to a method of analyzing the metabolic content of a biological sample comprising: i) providing one or more samples of extracted metabolites from the biological sample; ii) performing a chromatography coupled mass spectrometry analysis of the extracted metabolites to generate a full raw data set for full scan ions; iii) generating a full data cluster set from the full raw data set obtained in step ii) by grouping full scan ions according to isotope and adduct values; iv) performing a tandem mass spectrometry analysis of the extracted metabolites with a plurality of mass selection windows to generate a raw SWATH® data set for fragment ions; v) generating a SWATH® data cluster set from the raw SWATH® data set obtained in step iv) by grouping fragment ions according to retention time and mass values; vi) aligning the SWATH® data cluster set with the full data cluster set to generate characteristic profile for each extracted metabolite; vii) comparing the characteristic profile of each extracted metabolite obtained in step vi) with a reference library of characteristic profiles of metabolites to provide the metabolic content of the biological sample.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113419001-A
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