| abstract |
Disclosed are a cannabinoid nanomicelle preparation and a method for preparing same. The cannabinoid nanomicelle preparation comprises: a cannabinoid and an amphiphilic polymer. The content of the cannabinoid in percentage by weight is 1-40%, and the content of the amphiphilic polymer in percentage by weight is 1-99%. The preparation method comprises: (1) preparing the cannabinoid and the amphiphilic polymer into a cannabinoid nanomicelle solution; (2) drying the micelle solution obtained in step (1) to obtain the cannabinoid nanomicelle powder; and (3) preparing the cannabinoid nanomicelle powder obtained in step (2) into the cannabinoid nanomicelle preparation. According to the cannabinoid nanomicelle preparation, the active ingredient has high encapsulation rate and transfer rate, high drug loading capacity, and strong stability. A novel room temperature self-assembly technology is used to prevent the active ingredient cannabinoid from degrading and discoloring at high temperature. The active ingredient has high bioavailability, which can reduce the single dose. In particular, a dry powder inhaler has a high deposition rate in vitro and fast inhalation effect, and can provide a continuous and stable plasma concentration. |