| abstract |
The present invention relates to a fusion protein including a GDF15 variant having increased physiological activity and in vivo stability, and a pharmaceutical composition comprising the same. The GDF15 variant or long-acting GDF15 fusion protein, according to the present invention, is superior to conventional GDF15 variants in terms of in vivo efficacy, binding affinity for GDF15 receptors, and body weight loss effect. Therefore, a pharmaceutical composition, which comprises, as an active ingredient, the GDF15 variant, the long-acting GDF15 fusion protein, or a dimer of the fusion protein, of the present invention, causes appetite suppression, and thus can be effectively used as a therapeutic agent for metabolic diseases or obesity. Furthermore, the pharmaceutical composition, which comprises, as an active ingredient, the GDF15 variant, the long-acting GDF15 fusion protein, or the fusion protein dimer, can be used in combination therapy or the like with chemical drugs and other therapeutic agents for metabolic diseases, and can be effectively used in combination therapy with conventional therapeutic agents for metabolic diseases or obesity. |