http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021103700-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e7f2930df3427bd1e66eab5b3e5853b7 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1088 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6458 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 |
| filingDate | 2020-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97ac021fb23561590a4568a8c64dd2cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e32adb27ca0b1814794173ee2ed3e7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6435befa1242b5ae58a73ce07163b3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f5b51d26c14dd330b0868065bc134b7 |
| publicationDate | 2021-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2021103700-A1 |
| titleOfInvention | Nitroreductase responsive hypoxia probe compound, and preparation and application thereof |
| abstract | The present invention relates to a preparation method for a nitroreductase responsive fluorescent probe compound (I), and an application of a nitroreductase responsive fluorescent probe compound in hypoxia analysis and imaging. The fluorescent probe according to the present invention can achieve high-sensitivity and high-specificity response to tumor microenvironment hypoxia related nitroreductase. Moreover, the compound is prepared by means of a condensation reaction and has the molecular conjugation degree significantly increased, so that absorption and fluorescence emission wavelengths are significantly redshifted compared with coumarin, rhodamine and other dyes, and thus when the hypoxia probe is applied to analysis and imaging, the interference is small; the probe is constructed by means of an intramolecular charge transfer (ICT) mechanism, is a signal enhanced probe, and has a small background signal. |
| priorityDate | 2019-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 224.