| abstract |
This invention is the conjugate of formula (I) for treatment of tumors expressing PSMA, including PSMA-ligand with linker and antineoplastic agent MMAE, the composition for lyophilizate preparation based on it, the dosage form for therapy and obtained by the lyophilization of this composition, PSMA expressing prostate tumor growth inhibition, the solution for infusions or injections containing this dosage form, reconstituted by the solvent, comprising 95% ethyl alcohol and polysorbate 80 within mass ratio (30-60):(70-40), respectively. The technical result of the claimed group of inventions is the high affinity and selectivity of the action of the claimed conjugates in relation to PSMA expressing cells. 6 files of independent points and 6 files of dependent points, 15 illustrations, 27 tables, 7 notes. |