| abstract |
Disclosed are synergistic compositions comprising a therapeutically effective synergistic amount of a protein kinase B (Akt) activation inhibitor and a second inhibitor selected from a checkpoint (CHK1) inhibitor, a multitargeted histone deacetylase/human epidermal growth factor receptor (HDAC/Her1/2) inhibitor, a phosphoinositide 3-kinase (PI3K) inhibitor, or a combination thereof. Methods of using the disclosed compositions for treating, preventing, reducing, and/or inhibiting a cancer comprising administering the same to a subject are also disclosed. |