| abstract |
This invention provides a polypeptide represented by the following formula: H2N-A-X-B-A-X-B-HOOC wherein A represents consecutive amino acids, the sequence of which (1) includes a sequence identical to the sequence of amino acids 90 – 93 of wildtype HMGB1, (2) has at its amino terminal end, between one and six consecutiveamino acids, for example, 1, 2, 3, 4, 5, or 6 amino acids, the sequence of which isidentical to the sequence of the corresponding one to six amino acids preceding aminoacid 90 in wild type HMGB1, and optionally (3) has a methionine at the aminoterminus;wherein X represents consecutive amino acids, the sequence of which is identical to the sequence of amino acids 94 – 162 of wild type HMGB1; and wherein B represents consecutive amino acids, the sequence of which (1) includes a sequence identical to the sequence of amino acids 163 – 168 of wild type HMGB1 and (2) has at its carboxy terminal end, between one and six consecutive amino acids, for example, 1, 2, 3, 4, 5, or 6 amino acids, the sequence of which is identical to the sequence of the corresponding one to six amino acids following amino acid 168 in wild type HMGB1; and wherein each - represents a peptide bond between each of A and X, X and B, B and A, A and X, and X and B. |