| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c8cbbf2290b3f3a9988da29598baa2c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ea87e08ddf866d044e508503824f029
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3bb71a8f2a224885c5bd38dac3bf9c0d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4746 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2020-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fb6253793700d366f7d7b8ea80b50e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e3e6f4f398a837dc3274a92a0b989fb |
| publicationDate |
2021-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2021091871-A1 |
| titleOfInvention |
High affinity and dual-specificity peptide antagonists of mdm2 and mdmx for p53 activation |
| abstract |
Peptide antagonists of MDM2 and MDMX are disclosed. The peptide antagonists include antagonists of MDM2 or MDMX, as well as dual-specificity antagonists where the same peptide is an antagonist of both MDM2 and MDMX. The peptide antagonists have at least nanomolar binding affinity for MDM2 and/or MDMX, and in some cases picomolar binding affinity. The peptide antagonists can be used in methods based on blocking inhibition of p53 activity by MDM2 and/or MDMX. Such methods can be used in the treatment of diseases, such as cancer. |
| priorityDate |
2019-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |