abstract |
The invention relates to a composition comprising double-stranded RNAs (dsRNA) essentially consisting of dsRNA having two complementary strands, comprising at least one block or homopolymer of poly A and the complementary block or homopolymer of poly U, each block comprising at least 15, 20, 25 or 30 A, or U, each strand having a determined length of between 50 and 200 bases, preferably between 55 and 200 bases, all the strands or substantially all the strands have the determined length, and a pharmaceutically acceptable vehicle, carrier or excipient. The composition may be used in treating Non Muscle Invasive Bladder Cancer, Muscle Invasive Bladder Cancer or Metastatic Muscle Invasive Bladder Cancer. |