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filingDate 2020-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a452a27d227d2b06cdc0cbc33dc96b92
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publicationDate 2021-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2021087105-A1
titleOfInvention Immunotherapy with combination therapy comprising an immunotoxin
abstract Provided is a combination and a method of using combination therapy to treat tumor in an individual. An immunotoxin and an immunostimulator are administered to the individual, wherein the immunotoxin comprises a single chain variable region antibody fused to a PE38 truncated Pseudomonas exotoxin, and the immunostimulator comprises an anti-CD40 agonist antibody. The combination may further comprise a checkpoint inhibitor comprising one or more of an anti-PD- 1 antibody and an anti-PD-L1 antibody.
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