| abstract |
The present invention relates to a method for producing a composite demineralized bone matrix composition using a one-step process. The composite demineralized bone matrix composition, according to the present invention, is produced from biologically-derived bone. In addition, the composite demineralized bone matrix composition produced by the present invention contains bone mineral according to the original composition proportion in the bone, and may provide a bone mineral content condition which is closest to that in an environment in which in vivo bone formation occurs. In addition, the composition contains a bone morphogenetic protein (BMP-2), and thus enables a stable and excellent bone formation effect to be derived. |