| abstract |
Disclosed is a method for anchoring and modifying a nano-drug on the surface of a living cell. The method comprises: introducing an active reaction group to the surface of a living cell by means of a hydrophobic tail chain of a cell membrane anchoring molecule; modifying a corresponding reaction group on the surface of a nano-drug; and carrying out a biological orthogonal click reaction on the active reaction group modified on the surface of the living cell and the corresponding reaction group modified on the surface of the nano-drug, so as to anchor and modify the nano-drug to the surface of the cell to obtain a living cell with a modified nano-drug. The above-mentioned method is simple, convenient, quick and in common use, and can be applied to various cells with lipid membrane structures, including primary cells. The functions of the cells themselves are not influenced after such a modification. The method provides a new technical platform for cell modification and has very wide application prospects. Compared with pure cells and pure nano-drugs, a cell drug obtained by the above-mentioned cell modification technology has an optimal treatment effect and provides a new idea and a new drug for treating various diseases. |