| abstract |
Systems and methods of preparing therapeutic materials from amniotic tissue are discussed. In some embodiments the amniotic tissues are ground and used to generate hydrogels. Variations in the materials and preparation methods result in attributes, such as preservation of protein activity and/or thickening time, that are applicable to various therapeutic uses. As an illustrative example, a hydrogel of finely ground amniotic tissue can be freeze-dried and cryoground to particle sizes suitable for use in ophthalmic, oral, or other treatments. In some embodiments, the invention includes to a highly efficient and effective cryogenic grinding process and mechanic engineering design to make fine, uniform sizes and highly dissoluble powder particles for industry large scale manufacturing. This is accomplished while maintaining the original important physical, chemical and biological characteristics of the Materials being grinded. Exemplary embodiments include grinding of amniotic tissue, proteins, collagen, mucopolysaccharide and freeze-dried tissues, for the generation of therapeutic materials. |