| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d4d7c63dce10e31a74ba98f592bdca28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb314e9b624c4240a5fd2848a2cbc62e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate |
2020-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f405920f649f70d7dbef695446558791
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55b7ce5adb576e365f1c472757d81b47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb008c3d72c18ed0e19cc23e4f5dd9b9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75eb5d37143a004379163a62d06faf59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_119fb470ea7da99954e5ae1214202f5f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd2f7af242d64716caf0b2bafcc67f97
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2994e941ba074b5ecb77f62be4ddf9e4 |
| publicationDate |
2021-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2021078285-A1 |
| titleOfInvention |
Cycloalkyl-based and heterocycloalkyl-based inhibitors, preparation method therefor and use thereof |
| abstract |
The present invention relates to cycloalkyl-based and heterocycloalkyl-based inhibitors, a preparation method therefor and the use thereof. Specifically, the inhibitors have a structure as represented by formula (I). Further disclosed are a method for preparing such a compound and the use of same as a KRASG12C inhibitor. The compound has a good selective inhibition effect on KRASG12C, and has a better pharmacodynamic and pharmacokinetic performance and a lower toxicity and fewer side effects. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11702418-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022266206-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022262838-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11453683-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11548888-B2 |
| priorityDate |
2019-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |