| abstract |
Provided in the present invention is a small molecular compound, which is characterized in being a compound represented by the following structural formula or a stereoisomer, geometric isomer, tautomer, racemate, hydrate, solvate or metabolite thereof and a pharmaceutically acceptable salt or prodrug shown in formula (I): X1 and X2 are selected from carbon or nitrogen; Z is carbon or nitrogen; n1 is 0 or 1; n2 and n3 are the same or different, and are 0 or any natural number; the cyclic group represented by G is a saturated heterocyclic ring; any one or several hydrogen atoms on the saturated heterocyclic ring are substituted by R; and R is selected from hydrogen, halogen, alkyl, substituted alkyl, amino, amine, substituted amine, carboxy, amide, substituted amide, ester, substituted carbonyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, substituted sulfone, and substituted sulfoxide. The small molecular compound of the present invention may be used to treat, prevent and alleviate autoimmune diseases and/or immune-related inflammatory skin diseases. |