| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_04d9cb3e0dd7e1010d0b1e7f5f692832 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F2438-03 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F20-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F8-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F220-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F220-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0032
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F20-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F20-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F20-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 |
| filingDate |
2020-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eef0fa99cb7796be635b729481f9317d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03c41bf58580e9bb18ec88d70440c3a3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df1fd898548a0c7501c4e3fa62d555be |
| publicationDate |
2021-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2021073667-A1 |
| titleOfInvention |
Method for the preparation of polymeric carriers for ph- controlled drug release and their conjugates with drugs |
| abstract |
The present invention relates to an effective method of preparation of copolymers of N-(2-hydroxypropyl) methacrylamide (HPMA) and methacryloylaminoacylhydrazide, suitable for binding of drugs containing a keto group, for pH-controlled drug release. The method comprises the steps: a) providing of the monomers of the linear statistical copolymer; b) RAFT polymerisation of monomers of the linear statistical copolymer; c) introduction of hydrazide groups, and simultaneous in situ modification of the end groups of the linear statistical copolymer, optionally, binding a biologically active molecule to the ends of the polymer chain. The present invention further relates to a method of preparation of a conjugate of the linear statistical copolymer with a drug by means of a pH-sensitive hydrolysable hydrazone bond. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023036351-A1 |
| priorityDate |
2019-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |