| abstract |
Provided are a continuous post-treatment method and device for a penem compound. The method comprises the following steps: S1, performing continuous extraction on a reaction crude product of a penem compound to obtain an extraction heavy phase and an extraction light phase; S2, performing continuous solid-liquid separation on the extraction heavy phase to obtain a liquid phase separation product; S3, performing continuous pH adjustment on the liquid phase separation product until the pH value is 6.1-6.3 to obtain a pH-adjusted solution; and S4, performing continuous crystallization treatment on the pH-adjusted solution by using a first crystallization solvent to obtain a penem compound product. The use of the method for post-treatment of a reaction crude product of a penem compound has the advantages of high treatment speed and high efficiency, and stable material properties and a low deterioration rate during treatment, and has better control over the yield and purity of a target product. |