http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021064235-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e4f0548ee4ecf77e552c58c637d6aa11 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0634 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0696 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-15 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-15 |
filingDate | 2020-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11833b56083b7e958d0b8c39681378fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcf5ef8099858c766bd47ae3d3ca82b1 |
publicationDate | 2021-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | WO-2021064235-A1 |
titleOfInvention | Oligonucleotide based ex vivo cell therapy |
abstract | The present invention refers to a method for reducing expression of a target RNA in an isolated cell in preparation for cell therapy, comprising incubating the isolated cell comprising the target RNA with an antisense oligonucleotide without use of a transfection means, wherein the antisense oligonucleotide is administered to the isolated cell at least once in a time period of day 0 to day 21, the antisense oligonucleotide hybridizes with the target RNA and reduces the transcription of the target RNA, reduces the expression of the protein encoded by the target RNA or a combination thereof up to 8 weeks from day 0 of the incubation with the antisense oligonucleotide. The invention further relates to an isolated cell obtainable by the method of the present invention and a pharmaceutical composition comprising the isolated cell. The isolated cell and the pharmaceutical composition are used in a method of preventing and/or treating a disease. |
priorityDate | 2019-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 329.