| abstract |
The present invention relates to a RET inhibitor, a pharmaceutical composition thereof and use thereof in the pharmaceutical field. Specifically, the present invention relates to a compound represented by formula (I), or a stereoisomer, a geometric isomer, a tautomer, an oxynitride, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the compound represented by formula (I), the present invention also relates to a pharmaceutical composition comprising the compounds, and the use of the compounds and the pharmaceutical composition thereof in the preparation of a drug, the drug is particularly used for the treatment and prevention of diseases and conditions associated with available RET, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome. |