| abstract |
Provided is an immune effector cell expressing IL-15; the cells express IL-15 and recognize receptors for specific target antigens, or the cells express IL-15R binding molecules and receptors that recognize specific target antigens. Also provided are a nucleic acid molecule, an IL-15R binding molecule or IL-15 or IL-15 and chemokine expressed by said nucleic acid molecule, a chemokine receptor, a cytokine other than IL-7, an siRNA which reduces PD-1 expression, a protein which blocks the binding of PD-L1 to PD-1, or a safety switch. |