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publicationDate 2021-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2021057346-A1
titleOfInvention Immunogenic peptide fragment of metalloproteinase adamts-7 and application thereof in resisting against atherosclerosis and related diseases
abstract An immunogenic peptide fragment of metalloproteinase ADAMTS-7 and an application thereof in resisting against atherosclerosis and related diseases. Provided is a short peptide, comprising any one of the following: a short peptide of which the amino acid sequence shown in sequence 1 in a sequence listing; a short peptide of which the amino acid sequence is shown in sequence 2 in the sequence listing; a short peptide of which the amino acid sequence is shown in sequence 3 in the sequence listing; and a short peptide of which the amino acid sequence is shown in sequence 4 in the sequence listing. Also provided are a conjugate containing the short peptide, a vaccine containing the conjugate and an application thereof. The vaccine containing the short peptide may significantly inhibit neointima in vascular restenosis mouse models and atherosclerosis in high-fat fed mice, and may be used to prevent or treat atherosclerosis and/or vascular restenosis.
priorityDate 2019-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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