| abstract |
This method for inducing immature oocytes comprises introducing four kinds of genes including FIGLA, NOBOX, LHX8 and TBPL2 or transcription products or expression proteins thereof into at least one kind of cells selected from the group consisting of pluripotent stem cells, epiblast-like cells and primordial germ cells. This method for producing mature oocytes comprises: introducing four kinds of genes including FIGLA, NOBOX, LHX8 and TBPL2 or transcription products or expression proteins thereof into at least one kind of cells selected from the group consisting of pluripotent stem cells, epiblast-like cells and primordial germ cells; and, after the introduction, co-culturing the cells with ovarian somatic cells. |