| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c91c29db57efd4988b5891d0d7c888f9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-02 |
| filingDate |
2020-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b71c506e361b8ee0b0f7d9378560849
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d2f599ed5449e49afeec0e1335f9483
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24be9e6214c805a3100384c4b6bb5786 |
| publicationDate |
2021-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2021047137-A1 |
| titleOfInvention |
Medicine for treating periodontal disease caused by periodontal pathogen infection |
| abstract |
Provided is a medicine for treating periodontal ligament cell dysfunction and alveolar bone loss caused by periodontal pathogen infection, the medicine comprising IL-18 antibodies and/or IL-18R receptor siRNA exosomes. The medicine according to the present invention uses IL-18 antibodies and/or loaded IL-18R receptor siRNA exosomes as functional components, and binds same to IL-18 in periodontal tissue so as to inhibit periodontal ligament cells from secreting pro-inflammatory cytokines, and reduce the effect of periodontal supporting tissue loss and inflammatory cell infiltration that are caused by periodontal ligament cell dysfunction under inflamed conditions, thereby preventing the occurrence and development of periodontal disease, which has great potential application value for the clinical prevention and treatment of periodontal disease. |
| priorityDate |
2019-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |