| abstract |
Provided are compositions, combinations, and methods and uses for treating a subject having a tumor or lesion, including those not responsive or resistant to prior therapeutic treatments, such as prior immune checkpoint inhibitor treatments. In some aspects, the methods include administering to the subject a targeting molecule that binds CTLA-4 conjugated with phthalocyanine dye, such as IR700. In some cases, the methods include administering an immune modulatory agent. The tumor or lesion, in some cases, a first tumor, is illuminated with a wavelength of light suitable for the activation of the phthalocyanine dye of the conjugate. The provided methods and uses provide for growth inhibition, volume reduction, and elimination of tumors and tumor cells including primary tumors, metastatic tumor cells, and/or invasive tumor cells. Also provided are compositions, combinations, methods and uses for provoking or enhancing systemic and local immune responses and for synergistic responses against tumor growth. |