| abstract |
Disclosed are an AKR1C3 inhibitor or a pharmaceutically acceptable salt of same, a preparation method for same, and uses thereof. A structural optimization is performed with a nonsteroidal anti-inflammatory medicament, flurbiprofen, serving as a lead compound. Disclosed are the biphenyl AKR1C3 inhibitor as represented by formula (I) and the preparation method therefor. As proven in target activity tests, the compound of the present invention is provided with an activity for significantly inhibiting AKR1C3, can be further developed into a medicament for treating or preventing diseases by inhibiting aldehyde ketone reductase AKR1C3, and lays a molecular foundation for studies on mechanisms related to tumor resistance. |