http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021041469-A1

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publicationDate 2021-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2021041469-A1
titleOfInvention Method and apparatus for individualized administration of medicaments for enhanced safe delivery within a therapeutic range
abstract Techniques for generating a dosing protocol for an individual include receiving first and second and third data. First data indicates, for dose response to a medicament, a continuous multivariate model with at least one distribution parameter characterizing variations in the population. Second data indicates a therapeutic range of values for the dose response. Third data indicates a cost function based on distance of a dose response from the therapeutic range. The method includes evaluating for a candidate dose an expected cost based at least in part on the distribution parameter and a Koopman transform of the cost function. When the expected cost is less than a threshold cost, the candidate dose of the medicament is administered to a subject.
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