| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ddb9f3656270bc5410be3679322fead |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate |
2020-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c872f51893fb11b075cf2657cb9a1e66 |
| publicationDate |
2021-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2021039574-A1 |
| titleOfInvention |
Heavy-chain antibody in which o-linked sugar chain modification is suppressed |
| abstract |
The present invention provides, in order to obtain a uniform quality for heavy-chain antibodies, a heavy-chain antibody that is less susceptible to modification by O-linked sugar chains. The heavy-chain antibody according to the present invention is characterized by including a heavy chain variable domain having a structure of (FR1)-(VH-CDR1)-(FR2)-(VH-CDR2)-(FR3)-(VH-CDR3)-(FR4), wherein, in the amino acid sequence of FR3, at least one serine or threonine residue is substituted with an amino acid other than serine or threonine. The present invention also pertains to: a nucleic acid having a base sequence encoding the amino acid sequence of the heavy-chain antibody; and a vector and a host cell including said nucleic acid. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023282162-A1 |
| priorityDate |
2019-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |