| abstract |
A teriparatide sustained release gel injection solution, made of the following ingredients: teriparatide, a pH buffer component, bioadhesive material, temperature-sensitive gel material, a pH regulator, and a solvent; the temperature-sensitive gel material is selected from a combination of temperature-sensitive poloxamer and glycerin, the bioadhesive material is selected from chitosan, hyaluronic acid, cellulose derivatives, polyacrylic acid or a combination thereof, and the solvent is water. The present teriparatide sustained release gel injection solution has a sustained release lasting several days, significantly reducing the number of medicine administrations, increasing patient compliance and improving the therapeutic effect, and also avoiding the use of bacteriostatic agents whilst achieving the same effect. |