http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021026373-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c864ddc09feabd84a4b510ae987299d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f75e8923583040e9d90afa119ae96fa7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-00 |
| filingDate | 2020-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd4510a0cf48bfcd42dee9c34438d377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21d88ba6cefa73da64c6b8736205def9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1ea0427439ca62c4ca2dad3ee0f9854 |
| publicationDate | 2021-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2021026373-A1 |
| titleOfInvention | Pumpless platform for high-throughput dynamic multicellular culture and chemosensitivity evaluation |
| abstract | The described invention provides an ex vivo dynamic multiple myeloma (MM) cancer niche contained in a pumpless perfusion culture device. The dynamic MM cancer niche includes (a) a three-dimensional tissue construct containing a dynamic ex vivo bone marrow (BM) niche, which contains a mineralized bone-like tissue containing viable osteoblasts self- organized into cohesive multiple cell layers and an extracellular matrix secreted by the viable adherent osteoblasts; and a microenvironment dynamically perfused by nutrients and dissolved gas molecules; and (b) human myeloma cells seeded from a biospecimen composition comprising mononuclear cells and the multiple myeloma cells. The human myeloma cells are in contact with osteoblasts of the BM niche, and the viability of the human myeloma cells is maintained by the MM cancer niche. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023026034-A1 |
| priorityDate | 2019-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1759.