| abstract |
Disclosed are compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein — is a single bond, and each Y is N or CR4; or — is absent, and each Y is NRY, carbonyl, or C(RY)2, wherein each R1 is H or optionally substituted C1-6 alkyl; R1 is optionally substituted C1-6 alkyl or H; R3 is optionally substituted C1-9 heteroaryl or optionally substituted C1-9 heteroarylC1-6 alkyl; each R4 is hydrogen, halogen, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, or optionally substituted C2-6 alkynyl; X is hydrogen or halogen; and R2 is as defined in claim 1. Also disclosed are pharmaceutical compositions containing the compounds of formula (I) and methods for their preparation. The compounds of formula (I) may be inhibitors of Ataxia-telangiectasia and RAD-3 -related protein kinase (ATR) and used for the treatment of diseases or conditions such as cancers. |