| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ffd5528fd07384d7b07ab484ed5b143 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate |
2020-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_433269a5aa3b8f0e543cd61f2a1796f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68290f33521ee78fac51426fdc07ec68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0dd15f178ad8b307556569c0162c5a1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29ceacb2f36f78549c1aa719abef00ce |
| publicationDate |
2021-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2021007524-A3 |
| titleOfInvention |
Clonal hematopoiesis in tumor infiltrating leukocytes in breast cancer and secondary hematologic malignancies |
| abstract |
The present invention relates to clonal hematopoiesis mutations in leukocytes infiltrating primary breast cancers as a precursor to secondary hematologic malignancies. Disclosed herein are results from genomic analysis of microdissected breast cancer tumor cells and tumor-infiltrating leukocytes from breast cancer patients who subsequently developed leukemia. In a subset of the patients, mutations present in the leukemia were detected in the tumor-infiltrating leukocytes of the breast cancer prior to treatment. Thus, in at least some patients, tumor-infiltrating leukocytes in the primary breast cancer may harbor the ancestor of the future leukemogenic clone. |
| priorityDate |
2019-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |