| abstract |
Leptospirosis is the most common zoonotic disease in the world, mainly affecting tropical and subtropical countries. Caused by pathogenic leptospira, the progression of the disease is influence by the reaction of host response mechanisms that can lead to significant organ damage or even fatality. Here, we present an invention involving the use of gene expression marker complement factor I (CFI) that can complement in the early assessment of risk for the eventual development of pulmonary complications, such as severe respiratory distress and hemorrhage. Such marker may prove useful in deciding preemptive interventions, and in prodiving insights into pathogenesis of leptospirosis. |