| abstract |
Disclosed are a monoclonal antibody 10G12 and an application thereof. The present invention provides a monoclonal antibody, comprising a heavy chain variable region and a light chain variable region. The heavy chain variable region comprises three complementarity-determining regions, i.e., HCDR1, HCDR2, and HCDR3. The light chain variable region comprises three complementarity-determining regions, i.e., LCDR1, LCDR2, and LCDR3. The HCDR1, HCDR2, and HCDR3 are sequentially shown in sequence 2 of the sequence table from the N-terminus at positions 26-33, positions 51-66, and positions 97-109. The LCDR1, LCDR2, and LCDR3 are sequentially shown in sequence 4 of the sequence table from the N-terminus at positions 27-37, positions 55-57, and positions 94-102. On the basis of the clinical requirement, the inventors of the present invention have discovered an antibody 10G12 against human adenovirus type 7, which can be used to prevent adenovirus infection, and therefore has important biological and medical significance. |