http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021000928-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1303739a2c7edab095c91e3a226cc45 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-11 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-708 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
| filingDate | 2020-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc1dc23856c8341c06610bcd14ca098f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b855b1249de17f0c93a2894f762a2cb |
| publicationDate | 2021-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2021000928-A1 |
| titleOfInvention | Oligomeric nucleic acid molecule activating atoh1 gene and use thereof |
| abstract | Disclosed are an oligomeric nucleic acid and the use thereof in treating hearing loss. Also disclosed is a small activating nucleic acid molecule for treating hearing loss. The small activating nucleic acid molecule may be a double-stranded or single-stranded RNA molecule targeting the promoter region of an ATOH1 gene, comprising a first nucleic acid strand and a second nucleic acid strand. The double-stranded RNA molecule targeting the promoter region of the ATOH1 gene comprises two nucleic acid strands of 16-35 nucleotides in length, and either of the nucleic acid strands has at least 75% homology or complementarity with a target selected from the promoter region of the ATOH1 gene. The method of using the small activating nucleic acid molecule and a pharmaceutical composition optionally containing a pharmaceutically acceptable carrier can up-regulate the expression of the ATOH1 gene and the protein in cells and can treat diseases or conditions related to insufficient or decreased expression of the ATOH1 gene. |
| priorityDate | 2019-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.