abstract |
This document provides methods and materials for treating a mammal having Huntington's disease. For example, methods and materials for forming GABAergic neurons that are functionally integrated into the brain of a living mammal (e.g., a human) and/or for modifying one or both huntingtin ( Htt ) genes (or HTT RNAs or HTT polypeptides) present in a mammal with Huntington's disease are provided. |